Abstract: Objective To investigate the relationship between the rs2976392 polymorphism of the PSCA gene and the risk of gastric cancer. Methods A total of 155 patients with gastric cancer and 210 healthy controls were recruited in Shandong and genotyped at the rs2976392 locus using PCR-based DNA sequence analysis and direct DNA sequencing. Results GG，GA and AA genotypes were identified at the rs2976392 locus， with the following frequencies in patients（and controls）：GG，43.23%（50.95%）；GA， 41.94% （41.43%）；and AA， 14.84%（7.62%）.The risk of gastric cancer was significantly higher in individuals with a GA or AA genotype than in those with a GG genotype（GA：OR 1.19，95%CI 0.77-1.86；AA：OR 2.30，95%CI 1.13-4.66）. Conclusions Polymorphism at the rs2976392 locus of the PSCA gene is associated with the incidence of gastric cancer.

Key words: Stomach neoplasms, Gastric cancer, PSCA gene, Genetic polymorphism